Extended Data Fig. 8: Prediction of striatal activity from subregions of cortex, from other striatal domains, and from the cortex during passive periods.
From: Striatal activity topographically reflects cortical activity
a, Activity in each striatal domain predicted from subregions of cortex (indicated by white regions in diagrams below x-axis) or from the other two striatal domains (far right). Each curve shows the relative cross-validated fraction of explained variance ((R2region − R2full cortex)/R2full cortex) for the colour-coded striatal domain (mean ± s.e. across sessions). Predictions are best from the associated cortical regions (two-way ANOVA on session and cortical subregion, subregion DMS P = 4.6 × 10−3, DCS P = 4.8 × 10−5, DLS P = 3.1 × 10−85 across 77 sessions) and striatal activity is less well predicted from other striatal domains than from cortex (signed-rank test, DMS P = 1.6 × 10−10, DCS P = 2.1 × 10−5, DLS P = 8.4 × 10−10 across 77 sessions). b, Example wheel trace, deconvolved cortical fluorescence, visual cortical electrophysiology and striatal electrophysiology session in the passive context (viewing visual noise stimuli), showing coherent low-frequency oscillations in VISam and DMS (formatted as in Extended Data Fig. 4a, from the same session session). c, Cross-validated fraction of striatal variance explained from cortex in task versus passive contexts. Small dots, sessions; large dots, mean ± s.e. across sessions; colour, striatal domain. DMS is predicted slightly better from cortex in the passive state, but DCS and DLS are predicted slightly worse the passive state (signed-rank test, DMS P = 6.2 × 10−7, DCS P = 1.9 × 10−4, DLS P = 1.6 × 10−5 across 77 sessions). d, Variance of striatal activity across task and passive states, legend as in b. During the passive state, DMS exhibits more variance and DCS and DLS exhibit less variance (signed-rank test, DMS P = 3.0 × 10−6, DCS P = 1.3 × 10−4, DLS P = 1.1 × 10−10 across 77 sessions), matching the differences in predictability between states. e, Cross-validated fraction of striatal explained variance from the cortex vs. variance of striatal activity during task performance, legend as in b. Cortex-explained variance is consistently related to activity variance across domains (ANCOVA, domain P = 0.22, domain-activity variance interaction P = 0.76).
