Extended Data Fig. 8: Genomic characterization of PDXs from primary LUSC. | Nature

Extended Data Fig. 8: Genomic characterization of PDXs from primary LUSC.

From: Elevated NSD3 histone methylation activity drives squamous cell lung cancer

Extended Data Fig. 8: Genomic characterization of PDXs from primary LUSC.The alt text for this image may have been generated using AI.

a, Distribution of whole-genome copy number alterations in LUSC PDXs used in this study by OncoScan (Methods). Green lines, 3p11 amplification (including PIK3CA and SOX2); red lines, marks, 8p11–12 (for example, NSD3 and FGFR1 as shown); blue lines, biallelic deletion in 9p21.3 (including CDKN2A/B). b, Sanger sequencing analysis of NSD3 SET domain mutation status in collection of 37 LUSC PDXs identified NSD3T1232A mutation in one of the PDX samples (PDXT1232A) and wild-type NSD3 in other analysed PDXs.

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