Extended Data Fig. 10: Model of highly transcribed region interfering BIR.
From: Tracking break-induced replication shows that it stalls at roadblocks
a, Model of the block of BIR initiation by transcription. Left: For H-On transcription, BIR immobilizes rPolII, which leads to the block of BIR and transcription. Right: Co-D transcription also interferes with BIR initiation. b, Established BIR can traverse transcription units in both orientations, even though it is associated with transient accumulation of rPolII at TES and leads to increased level of GCRs and mutagenesis in H-On orientation.
