Extended Data Fig. 5: Integration with snATAC-seq and epi-retro-seq.
From: DNA methylation atlas of the mouse brain at single-cell resolution
a–d, Integration UMAP for snmC-seq2 cells and snATAC-seq pseudo-cells from each cell group: excitatory IT neurons (a), other excitatory neurons (b), inhibitory neurons (c) and non-neuronal cells (d). Each panel is coloured by subtypes from the corresponding study, the other dataset is shown in grey in the background. e, Overlap score matrix matching the 160 a-types to the 161 m-types. f, mCG fraction (left), and chromatin accessibility (right) of cluster-specific CG-DMRs (columns) in HIP subtypes (rows). g, h, Same integration t-SNE as Fig. 2g, i coloured by the dissection regions but using all cells profiled by epi-retro-seq (g) or snmC-seq2 (h), cells from brain regions that have only been profiled via one of the methods are circled out. i, Same t-SNE as (h) coloured by snmC-seq2 subtypes. j, Overlap score matrix matching the subtypes to the ‘Soma Location (source)’ and ‘Projection target’ information labels of epi-retro-seq cells.
