Fig. 3: Relating genes and regulatory elements to cell subtype taxonomy.
From: DNA methylation atlas of the mouse brain at single-cell resolution
a, Schematic of the two characteristics contained in the methylome profiles. b, c, Pairwise CH-DMG (b) and CG-DMR (c) counts between 68 excitatory subtypes. c, In each CG-DMR set, we further identify differentially enriched motifs (left). TF, transcription factor. d, Excitatory subtype taxonomy tree. e, Top impact scores of ranked genes for the left and right branches of nodes 1–7 in d. The top four genes are transcription factor genes (bold); these are followed by other protein-coding genes. The scatter plots below show cells involved in each branch. f, Branch-specific transcription factor motif families. The zoomed UMAPs show individual transcription factor genes in those families, whose differential mCH fractions are concordant with their motif enrichment.
