Fig. 5: Brain-wide spatial gradients of DNA methylation.
From: DNA methylation atlas of the mouse brain at single-cell resolution
a, UMAP for cortex IT neurons coloured by dissection regions. b, The 21 cortical dissection regions organized by spatial axis. c, Normalized mCH fraction of spatial CH-DMGs, with the same layout as b. d, UMAPs for DG granule cells coloured by their cell global mCH fractions and dissection regions. A, anterior; P, posterior; D, dorsal; V, ventral. e, Compound figure showing four cells groups organized according to DG gradient and the two gradient DMR groups separated according to the sign of the correlation to the cell’s global mCH level. f, g, Bottom, expression (z-score across rows) of genes positively (f) or negatively (g) correlated with DMRs across cell types along the granule cell maturation pathway33. Top, genome browser views of representative genes.
