Extended Data Fig. 2: PfHT1 has evolved to be an efficient polyspecific sugar transporter.
From: The molecular basis for sugar import in malaria parasites
a, Size-exclusion chromatogram of DDM-purified PfHT1 showing PfHT1 migrates as two oligomeric species (dimer and monomer); the sample migrates as a monomer during SDS–PAGE. b, Time-dependent uptake of [14C]d-mannose (black circles) by PfHT1 in proteoliposomes. Inset, PfHT1 uptake of radiolabelled sugar (cyan trace) compared with non-specific uptake estimated from radioactivity measured from liposomes incubated without protein (black trace). Error bars represent the mean ± s.e.m. of n = 3 biologically independent experiments. c, As in b, for [14C]d-galactose. d, As in b, for [14C]d-fructose. e, As in b, for [3H]d-xylose. f, As in b, for [3H]d-glucosamine.
