Extended Data Fig. 9: Roadmap epigenome marks overlapping flanking intervals with somatic burden. | Nature

Extended Data Fig. 9: Roadmap epigenome marks overlapping flanking intervals with somatic burden.

From: Genomic basis for RNA alterations in cancer

Extended Data Fig. 9

a, Maximum fold enrichment of epigenetic marks from the Roadmap Epigenomics Project across 127 cell lines. The number of cell lines with significant enrichments is indicated in parentheses (FDR ≤ 10%); asterisks denote significant enrichments in at least one cell line. b, Mean percentages (over the 127 cell lines) of regions overlapping (by at least 10% of their length) Roadmap epigenome marks, calculated using all genomic flanking regions (n = 1,637,638) and the subset of 556 flanking intervals associated with somatic eQTL (FDR ≤ 5%). c, Mutation rate per kilobase. d, Burden frequency (across the 127 cell lines) of the 556 flanking intervals in somatic eQTLs (FDR ≤ 5%), overlapping 25 Roadmap epigenome marks. DNase, DNase only; EnhA, active enhancer; EnhAc, enhancer acetylation only; EnhAF, active enhancer flank; EnhW, weak enhancer; Het, heterochromatin; PromBiv, bivalent promoters; PromD, promoter downstream; PromP, poised promoters; PromU, promoter upstream; Quies, quiescent/low; ReprPC, repressed PolyComb; TssA, active TSS; TxReg, transcription regulatory; ZNF/Rpts, ZNF genes and repeats; Tx, transcription; Tx3, transcription 3′, Tx5, transcription 5′; TxEnh3, transcription 3′ enhancer; TxEnh5, transcription 5′ enhancer; TxEnhW, transcription weak enhancer; TxWk, weak transcription.

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