Extended Data Fig. 14: Determinants of AEI.
a, Standardized effect sizes on the presence of AEI, taking only SCNAs, germline eQTLs, coding and non-coding mutations into account. In summary, SCNAs accounted for 86.1% of the total effect size, followed by germline eQTLs (9.0%) and somatic SNVs (4.8%). b, Relevance of individual somatic mutation types (‘copy-number ht1’ and ‘copy-number ht2’ as local allele-specific SCNAs of haplotypes 1 and 2, respectively), germline eQTLs and other covariates for the ASE ratio. Significant covariates (FDR ≤ 5%) are highlighted in bold. c, Comparison of the effect of protein-truncating variants (stop-gained) and synonymous variants on the ASE ratio.
