Extended Data Fig. 22: Breakdown of DNA and RNA alterations of cancer genes. | Nature

Extended Data Fig. 22: Breakdown of DNA and RNA alterations of cancer genes.

From: Genomic basis for RNA alterations in cancer

Extended Data Fig. 22

a, Composite pie charts showing percentages of DNA and RNA alterations for top cancer-driver genes. The 20 most significant cancer-driver genes identified by the PCAWG group in pan-cancer level are depicted, with the sizes of the pie charts indicating the percentages of patients carrying alterations in the given driver gene. The areas represent the relative percentages of patients exhibiting different alterations depicted by corresponding colours. When several types of alteration in one pathway affect the same patient, only a fraction is counted towards each type of alteration. b, Proportional bar plots showing the distribution of gene alterations for genes in the TP53 and TGFB pathways.

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