Fig. 4: Global view of DNA and RNA alterations that affect tumours.

a, The median numbers of different alterations across histotypes. Histotypes are ordered by hierarchical clustering based on the pattern of different types of alteration. Only histotypes with more than 10 donors are shown. Alt., alternative; non-syn, non-synonymous. Cancer-type abbreviations are listed in Supplementary Table 23. b, c, Circular representations of the selected genes significantly co-occurred with B2M (b) and PCBP2 (c). Connecting lines indicate the specific types of co-occurrence of alteration pairs. The inner histograms indicate the frequencies of incidences of different alteration types shown in different colours. d, All 74 Catalogue of Somatic Mutations in Cancer (COSMIC) cancer census genes or PCAWG driver genes that are both frequently and heterogeneously altered across both RNA- and DNA-level alterations. Yellow bars indicate the proportion of samples that had DNA-level alterations, and green bars indicate the proportion of samples with RNA-level alterations. Middle column is the proportion of each alteration type observed for that gene. e, The enrichment of cancer genes within our list of significantly recurrent genes.