Extended Data Fig. 8: Docking position of GPR52 agonists, structural similarity network and sequence alignment of GPR52. | Nature

Extended Data Fig. 8: Docking position of GPR52 agonists, structural similarity network and sequence alignment of GPR52.

From: Structural basis of ligand recognition and self-activation of orphan GPR52

Extended Data Fig. 8: Docking position of GPR52 agonists, structural similarity network and sequence alignment of GPR52.The alternative text for this image may have been generated using AI.

a, Docking position of GPR52 agonists with different scaffolds: WO-459 (left); 7m (centre) and FTBMT (right). The PR52 residues that are involved in ligand binding are shown as green sticks and c17 is shown as grey sticks, for reference. b, Structural similarity network of class-A GPCRs with reported inactive structures. c, Sequence alignment of GPR52 and GPR21 (yellow, less than 5.0 Å to ligand; green indicates key residues for structural features).

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