Extended Data Fig. 2: Concentration–response curves of notable analogues based on initial hits in cAMP assays.
From: Virtual discovery of melatonin receptor ligands to modulate circadian rhythms
a–f, Inhibition of isoproterenol-stimulated cAMP mediated by hMT1 (a, c, e) or hMT2 (b, d, f) in HEK293T cells by melatonin and select analogues. Data are normalized to the melatonin response. The compounds were split into three graphs for clarity, melatonin response curves are the same across graphs in a, c, e and b, d, f. Data are mean ± s.e.m. of four biologically independent experiments (n = 4) run in triplicate, unless otherwise indicated, in which case the number of biologically independent experiments is indicated in parentheses next to the compound name.
