Extended Data Fig. 4: Effect of ablation on L2/3 model sensory representation increases with the number of ablated neurons.
Ablation effect (change in Rstimulus) as a function of the degree of touch representation degradation (net Rstimulus across ablated neurons). In all cases, we used increased subnetwork connectivity (0.4) (Fig. 1, Methods). The nablated neurons with the highest encoding score were selected for ablation. Grey circles denote individual networks. Black dots denote, median across n = 30 simulated networks for a given number of ablated neurons, indicated in the plot. Beyond nablated > 50, we observed instability, presumably because we did not attempt to restore excitatory-inhibitory balance after ablation; these data were omitted. Correlation of net Rstimulus ablated and ΔRstimulus: R = −0.65, P < 0.01.
