Extended Data Fig. 9: Chromatin state dynamics and signature of PcG repression at key regulators.
From: An atlas of dynamic chromatin landscapes in mouse fetal development
a, The most enriched biological processes (GO terms) for genes near putative liver enhancers (n = 4,595). The significantly enriched terms for each stage were identified and divided into deciles (based on statistical significance). The ten most enriched terms for each stage were then grouped together and hierarchically clustered. Genes involved in either haematopoiesis or metabolic processes are colour-coded, as indicated. P values from binomial test (GREAT); FDR is Benjamini–Hochberg corrected q value. b, Genome browser views showing tissue-restricted activity patterns at Cdx2 (chr5: 147,294,550–147,313,599; mm10), Barx1 (chr13: 48,649,148–48,680,395; mm10), Nkx2-1 (chr12: 56,507,647–56,560,509; mm10), and Wt1 (chr2: 105,097,427–105,200,306). c, Left, the number of TSSs marked by Hc-P in each tissue-stage. Right, the number of genes with at least one annotated TSS marked by Hc-P in each tissue-stage.
