Extended Data Fig. 11: Current model of Hodor functions.
From: An intestinal zinc sensor regulates food intake and developmental growth
Hodor resides in the apical membrane and on the lysosomes of gut interstitial cells (highlighted in blue, adjacent to acid-secreting copper cells (#). Zinc sensing by Hodor promotes chloride transport and Tor signalling within interstitial cells. Hodor/Tor signalling in interstitial cells in turn promotes systemic growth through a neural relay, activating insulin-like signalling and thereby sustaining developmental rate, and by promoting food intake via an as-yet unknown mechanism that is independent of the insulin-producing cells of the brain. The reduced insulin signalling observed in hodor mutants may be secondary to their reduced food intake, hence the dashed arrow.
