Extended Data Fig. 1: Intracranial self-stimulation in the presence and absence of 9D7. | Nature

Extended Data Fig. 1: Intracranial self-stimulation in the presence and absence of 9D7.

From: Local and global consequences of reward-evoked striatal dopamine release

Extended Data Fig. 1: Intracranial self-stimulation in the presence and absence of 9D7.

Behaviourally shaped rats implanted with unilateral cannulae targeting the ventral striatum performed intracranial self-stimulation during continuous injection of 500 μM of the dopamine sensor 9D7 (blue) or saline vehicle (grey), under infusion conditions used for imaging experiments. The number of rewards received per trial is graphed, relative to rewards received before infusion, showing no significant difference between infusion of 9D7 versus saline. Error bars denote s.e.m. of data from n = 5 rats each.

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