Extended Data Fig. 5: IpRGC input to SCN during early postnatal stages influences afferent IGLNPY projections.
From: Retinal innervation tunes circuits that drive nonphotic entrainment to food
a, Npycre/+ mice, with or without bilateral enucleation at P0, were injected in the IGL with Cre-dependent AAV-tdT-Syn-GFP. b, Representative IGL injections in adult control and P0 enucleated Npycre/+ mice are shown. Three independent experiments were performed with similar results. c, d, Axonal projections (tdTomato) (red) from IGLNPY cells and their synaptic terminals (syn–GFP) (green) are shown (c). IGLNPY synaptic terminals were quantified (d). Data are mean ± s.e.m. (n = 3 mice for each condition), two-tailed Student’s t-test. Scale bars, 200 μm (b), 100 μm (c).
