Extended Data Fig. 1: Clonality of endometrial glands and driver mutations.

a, The majority of the sampled normal endometrial glands (n = 257 individual endometrial glands) were clonal with a median VAF for all identified indels of 0.3 or above. b, The presence of a driver mutation did not have a significant effect on the observed monoclonality of the glands (two-sided Mann–Whitney U-test, P = 0.1). Here, we compared the median VAF of endometrial glands with drivers (median = 0.33, range 0.17–0.5, n = 145) to that of glands without drivers (median = 0.31, range 0.16–0.5, n = 112). Box plots were constructed with the upper and lower edge of the box defining the 25th (Q1) and 75th (Q3) percentile, respectively, outliers (plotted as circles) are defined as values beyond the whiskers (upper, Q1 − 1.5 × interquartile range (IQR) and lower Q3 + 1.5 × IQR). c, All glands from the 19-year-old donor (donor PD37506) (n = 10 individual endometrial glands) were clonal with a median VAF ≥ 0.3, but there were no detectable driver mutations.