Extended Data Fig. 7: Some recurrent PP GC clonotypes do not show selected SHMs.
From: BCR selection and affinity maturation in Peyer’s patch germinal centres
a–c, SHM profile of Vh segments of the indicated PP GC clonotypes and intrinsic mutation pattern, plotted as the mutation rate at each nucleotide. Sequences were stratified by the overall Vh mutation rate19 (see Methods). Significance was determined by hierarchical Bayesian modelling with PEP0.1 (see Methods; NS, PEP0.1 ≥ 0.05). Data are mean + s.e.m. from mice containing the indicated clonotype: n = 7 SPF mice, 10 pools of 3 germ-free mice, 4 GF + SFB mice and 6 GF + SPF mice (a), 4 SPF mice (b) and 9 pools of 3 germ-free mice (c).
