Extended Data Fig. 8: Recurrent PP GC IgH clonotypes are often associated with recurrent IgL clonotypes.
From: BCR selection and affinity maturation in Peyer’s patch germinal centres
a, Vl repertoire of productive VJ junctions in PP GC B cell versus naive B cells. Data are plotted as mean + s.e.m. from 9 SPF mice (related to Fig. 1). The distribution of productive clonotypes of each indicated Vl segment in the GCs is shown as a long-tail-distribution plot, with the y axis representing the fraction of each productive clonotype among all productive clonotypes and the x axis representing the top clonotypes (rank-ordered). The number of mice that contained the clonotype is indicated for dominant recurrent clonotypes. P values for Vl usage were calculated by two-sided Mann–Whitney U test with FDR correction (*P < 0.1, **P < 0.05, ***P < 0.01, NS, not significant). See Supplementary Table 4 for exact P values. b, Table showing the paired IgL clonotype of recurrent PP GC IgH clonotypes, as inferred by Rep-SHM-Seq (see Methods) from nine SPF mice and/or detected by scRNA-seq from four SPF mice.
