Extended Data Fig. 1: Sequence alignment of human and mouse ACAT1, ACAT2 and DGAT1. | Nature

Extended Data Fig. 1: Sequence alignment of human and mouse ACAT1, ACAT2 and DGAT1.

From: Structural basis for catalysis and substrate specificity of human ACAT1

Extended Data Fig. 1

Secondary structural elements of human ACAT1 are indicated above the sequences according to the present cryo-EM structure. Invariant and highly conserved residues are shaded yellow and grey, respectively. The conserved residue His460 at the active site is shaded red and coloured white. The conserved FYXDWWN motif and predicted cholesterol binding motif are indicated with blue and orange boxes, respectively. Sequences from human (h) and mouse (m) were aligned using the online MultiAlin server (http://multalin.toulouse.inra.fr).

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