Extended Data Table 1 Binding capacity, neutralizing activity, and gene family analysis of 18 monoclonal Abs isolated from patient no. 1 and patient no. 2

From: Human neutralizing antibodies elicited by SARS-CoV-2 infection

  1. The program IMGT/V-QUEST was applied to analyse gene germline, CDR3 length, and SHM. The CDR3 length was calculated from amino acids sequences. The SHM frequency was calculated from the mutated nucleotides. Antibody binding to RBD was presented either by Kd or by competing with ACE2, in which ‘+++’ indicates >80% competition; ‘++’ 50–80%; ‘+’ 20–50%; and ‘−’ <20%. IC50 represents the half-maximal whereas IC80 the 80% inhibitory concentrations in the pseudovirus and live SARS-CoV-2 neutralization assay. n.d. not done.
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