Extended Data Fig. 4: Pathological changes in lungs of rhesus macaques infected with SARS-CoV-2 and treated with remdesivir.
From: Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2
Rhesus macaques infected with SARS-CoV-2 and treated with remdesivir (n = 6) or vehicle solution (n = 6) were euthanized on 7 dpi. a, The area of each individual lung lobe affected by gross lesions as scored by a veterinary pathologist blinded to group assignment of the animals. b, All data from panel a combined. c, Lung weight: bodyweight ratio as an indicator of pulmonary oedema. d, Cumulative histology score. Each lung lobe was scored for the presence of histological lung lesions on a predetermined scale (0–4); these values were combined per animal and graphed. Data in panel a were analysed using a 2-way ANOVA with Sidak’s multiple comparisons test; data in b–d were analysed using a two-tailed, unpaired t-test. The centre bar represents the median.
