Fig. 1: Plasma antibodies against SARS-CoV-2.
From: Convergent antibody responses to SARS-CoV-2 in convalescent individuals
a–d, Results of ELISAs measuring plasma reactivity to RBD (a, b) and S protein (c, d). a, Anti-RBD IgG. b, Anti-RBD IgM. c, Anti-S IgG. d, Anti-S IgM. Left, optical density at 450 nm (OD450 nm) for the indicated reciprocal plasma dilutions. Right, the normalized area under the curve (AUC) for the 8 controls and 149 individuals in the cohort. Negative controls are shown in black; individuals 21 and 47 are shown as blue and red lines or arrowheads, respectively. e, Time between symptom onset and time of sample collection in days is plotted against the normalized AUC for IgM binding to RBD. r = −0.5517, P < 0.0001. f, Participant age in years is plotted against normalized AUC for IgG binding to RBD. r = 0.1827 and P = 0.0258. The r and P values in e and f were determined by two-tailed Spearman’s correlations. g, Normalized AUC of anti-RBD IgG ELISA for outpatients (n = 138) and hospitalized individuals (n = 11). P = 0.0178. h, Normalized AUC of anti-RBD IgG ELISA for men (n = 83) and women (n = 66). P = 0.0063. For g and h, horizontal bars indicate median values. Statistical significance was determined using two-tailed Mann–Whitney U-tests.
