Extended Data Fig. 6: H3.3S31ph and other H3 PTMs at response genes and after stimulation. | Nature

Extended Data Fig. 6: H3.3S31ph and other H3 PTMs at response genes and after stimulation.

From: Histone H3.3 phosphorylation amplifies stimulation-induced transcription

Extended Data Fig. 6: H3.3S31ph and other H3 PTMs at response genes and after stimulation.

a, ChIP–seq density fold change comparing the set of all genes to RNA-seq-defined LPS-stimulated genes for H3.3, K27ac, K36me2, K36me3, S28ph and S31ph. b, Average gene profiles shown here are H3K27ac, H3.3S31ph, H3K36me2, H3K36me3, H3S28ph and H3.3) comparing RNA-seq-defined LPS-induced genes before and after stimulation. c, Cumulative distribution function plots for H3K27ac H3K36me2, H3K36me3, H3S28ph, H3.3 and H3.3S31ph reveal selective role of H3.3S31ph compared with the ubiquitous role of H3K36me3. ***P < 0.0001, Student’s t-test.

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