Extended Data Fig. 10: Regulatory mechanisms of ubiquitous genes.
From: The changing mouse embryo transcriptome at whole tissue and single-cell resolution
a–c, Cumulative distribution function plots of polyA RNA-seq measurements from skeletal muscle (a), C2C12 GRO-seq data (b) and average 3′UTR length (c) are compared among three equal-sized groups of ubiquitous genes defined by their RNA-seq abundance. d, Comparisons of 3′UTR length, GRO-seq, Bru-seq and polyA RNA-seq assays among multiple different samples. Pearson correlation scores between each pair of measurements on the columns and rows are visualized using a heat map. In the corresponding cell of the comparison, a scatter plot is provided. On the diagonal are histograms of each individual measurement. n = 24,832 detectable genes. e, Significance of ETS motif enrichment in the promoters of ubiquitous genes determined using AME in MEME suite. n = 1,000 each for high, medium and low groups. f, A model is proposed that longer 3′UTR may harbour more binding sites for RNA-decay apparatus, leading to lower abundance at steady states.
