Fig. 2: Promoter motif codes for dynamic expression clusters of Fig. 1.
From: The changing mouse embryo transcriptome at whole tissue and single-cell resolution
a, Flowchart for motif enrichment analysis. b, A computed graph summary of unique and shared TF recognition sequence motifs. TF motif nodes are labelled as in the CIS-BP database55 where all uppercase indicates a human-derived motif and mixed case indicates a mouse-derived motif, and the respective gene cluster source nodes are coloured and numbered per the gene expression clustering in Fig. 1c. Edges connect a motif node with the expression cluster node(s) in which it was enriched, with edge thickness indicating significance (–log10P). Grey, motifs enriched in more than one cluster; yellow, unique enrichment. The size of each source expression cluster node is proportional to the scaled number of genes in the corresponding cluster.
