Extended Data Fig. 4: Ribosomal proteins and translation processes are altered in Nlgn3KO mice.
From: Rescue of oxytocin response and social behaviour in a mouse model of autism
a, TMT proteomics: graphs plotting abundance of dopamine markers and synaptic proteins from VTA, cortex and hippocampus. Dopaminergic markers are strongly enriched in VTA samples. n = 5 mice per brain region. b, c, Proteomic analysis of wild-type and Nlgn3KO VTA, n = 5 mice per genotype. b, Enrichment of GO terms for biological processes for proteins significantly altered (P < 0.05) in Nlgn3KO mice compared to wild-type mice. c, Network-based analysis of proteins altered in Nlgn3KO VTA (P < 0.01). Blue nodes indicate downregulated proteins, red nodes upregulated proteins, light blue lines indicate interactions known from database and purple lines interactions experimentally determined. Disconnected nodes and nodes containing less than six proteins are not shown. See methods for additional information of statistics and analysis parameters. d, Mean puromycin incorporation in acute cortical slices from adult wild-type and Nlgn3KO mice. All error bars are s.e.m. P values determined by two-sided Mann–Whitney U test. See Supplementary information for additional statistics.
