Fig. 1: Structural domains, homology and MHC-II epitopes of the SARS-CoV-2 S protein.
From: SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19
a, The S protein of SARS-CoV-2 (1,237 amino acids) is separated at the cleavage site (CS) into subunit S1, which comprises the receptor-binding domain (RBD), and subunit S2 which contains the fusion peptide (FP), the transmembrane domain (TM) and the cytoplasmic peptide (CP). Sequence homology of S proteins of SARS-CoV-2, SARS-CoV and hCoV strains NL63, 229E, HKU1 and OC43 was calculated as the percentage of amino acid identity in sliding windows of 10 amino acids and is depicted as grey vertical lines. Predicted SARS-CoV MHC-II epitopes are indicated as small horizontal lines. Sequences and references are listed in Extended Data Table 1. Homology is depicted for each reported MHC-II epitope in Extended Data Fig. 1. S-I spans the N-terminal region of S and S-II spans the C-terminal part of S, as indicated above the alignment. b, Proportion of sequence identity of the N-terminal and C-terminal parts of the S protein of SARS-CoV-2 and the S proteins of hCoV strains NL63, 229E, HKU1 and OC43.
