Fig. 2: Humoral and cellular immune responses to ChAdOx1 nCoV-19 vaccination in rhesus macaques.
From: ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques
a, Study schedule for NHPs. C, examination and challenge; E, examination; N, examination and necropsy; V, vaccination. b, Endpoint IgG titre in serum against trimeric spike protein. log10-transformed IgG endpoint titrations are shown, which were obtained by enzyme-linked immunosorbent assay (ELISA). c, log10-transformed virus-neutralizing titres in the serum. d, Summed IFNγ ELISpot responses in peripheral blood mononuclear cells collected on the day of challenge to peptides that span the full length of the spike protein. Red circles, prime-only vaccine; blue squares, prime–boost vaccine; green triangles, controls. The dotted line shows the limit of detection. *P = 0.0313. Statistical significance was determined using two-tailed signed-rank Wilcoxon tests.
