Extended Data Table 1 Cryo-EM data collection and model refinement statistics

From: Structure of LRRK2 in Parkinson’s disease and model for microtubule interaction

  1. The model refinement statistics are reported for four different types of model, two including GDP-Mg2+ in the ROC domain and two excluding it. In each case, we report statistics for two types of model: ‘Monomer w/interfaces’ consists of an LRRK2RCKW monomer plus fragments from the neighbouring monomers in the C3 trimer that were used during model building and refinement; ‘Top 10 monomers’ are the top-10 results from Rosetta Relax with the neighbouring fragments removed after processing in Rosetta. PDB accession numbers for the models and the EMD code of the maps used for model-building and refinement are indicated. EMD-21250 contains both the C3 map of the LRRK2RCKW trimer used to build the COR-B, kinase and WD40 domains and the signal-subtracted monomer used to build the ROC and COR-A domains. The final models reported here were refined into the signal-subtracted monomer map (Methods) *C3 reconstruction.
  2. #Signal-subtracted monomer.
  3. aWD40-mediated dimer.
  4. bCOR-mediated dimer.
  5. **Numbers represent the average of the values for all 10 models.
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