Extended Data Fig. 1: Overview of radical side-chain installation and relevant previous literature.
From: Light-driven post-translational installation of reactive protein side chains
a, Retrosynthetic analysis highlights the chemoselective advantages of using carbon radical reagents paired with the radical acceptor Dha (right) over the typical heterolytic 2e− reagents (left) for the site-specific modification of proteins. b, c, Our previous work on radical addition to Dha14,17 (b) and the mechanism highlighting unwanted side reactions (red) (c). d, e, Summaries of previous works24,25 using photocatalysts for ‘on-peptide’ radical generation for site-selective peptide modification, highlighting their limitations and potential for undesired side reactions (red).
