Extended Data Fig. 7: Structurally conserved loop for protein–protein interactions in MAB21 family nucleotidyltransferases.
From: Structural basis for sequestration and autoinhibition of cGAS by chromatin
Structures of cGAS–nucleosome (blue) and MID49–DRP1 (red, PDB code 5WP9). The structurally conserved loop is depicted in green, showing interacting residues. Dashed lines represent hydrogen bonds. Positively charged, basic amino acids on the nucleotidyltransferase loop interact with the acidic patch of the nucleosome or with the protein DRP1, respectively.
