Extended Data Fig. 1: cGAS binds nucleosomes even in the presence of free DNA.
From: Structural basis for sequestration and autoinhibition of cGAS by chromatin
a, Gel-mobility shift binding analysis of purified cGAS and nucleosomes. Nucleosomes without linker DNA (0N0) were tested for binding to purified human (h) and mouse (m) full-length cGAS and cGAScat. Data are representative of two biological replicates. b, Human cGAS activity assay preincubated with dsDNA followed by titration of 0N0 nucleosomes. Data are representative of two biological replicates.
