Extended Data Fig. 3: Sample density maps for cGAS–nucleosome structure.
From: Structural basis for sequestration and autoinhibition of cGAS by chromatin
a, Representative examples of cryo-EM map areas of cGAS, nucleosomal DNA and histones used for model building. b, Electron density for cGAS (blue) and H2A–H2B (yellow, red) interacting residues in interface I and interface II. cGAS tethering loops 1 and 2 with key interacting residues R222 and R241 are depicted as well as DNA-binding site B residues. Dashed lines represent hydrogen bonds.
