Extended Data Fig. 9: Strength of assembly activity during the social-memory discrimination task.
From: Hippocampal CA2 sharp-wave ripples reactivate and promote social memory
a, Distribution of assembly social-gain values from different regions. Assembly social gain is defined as the mean assembly strength during exploration within the interaction zone, divided by the mean assembly strength during exploration outside the interaction zone. Social gain was significantly greater than 1 for CA1 (P < 10−6; rank-sign and CA2 (P < 10−19) but not CA3 (P > 0.05). b, The left pair of bars shows socially related assembly strength ((assembly strength inside social interaction zone minus strength outside social interaction zone)/(sum of strengths)) for social-discriminant and non-discriminant assemblies (P < 10−3; rank-sum test). The right pair of bars shows that the normalized social-discrimination assembly strength (the difference between assembly strength during interaction with the preferred mouse minus the strength during the interaction with the other mouse, divided by the sum of these two strengths) was greater for discriminant compared with non-discriminant assemblies (P < 10−8). c, Discriminant assemblies were reactivated during the recall trial significantly more strongly than non-discriminant assemblies (P = 0.0421). d–f, Average peri-SWR activation of discriminant and non-discriminant assemblies in different hippocampal regions is shown for: d, CA1, n = 116, P = 0.0252; e, CA2, n = 213, P = 0.0144; and f, CA3, n = 59, P > 0.05.
