Extended Data Table 1 Classification and structural properties of SARS-CoV-2 RBD-specific antibodies

From: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

  1. IGHV, immunoglobulin heavy chain variable gene segment; IGLV, immunoglobulin light chain variable gene segment. V gene segments, somatic hypermutation information, CDR lengths, IC50 and IC90 values for NAbs in this study are from ref. 32. The following references are cited in the table: refs. 6,9,10,13,26,27,28,30,34,38,41,67,68,69.
  2. ^Average human antibody CDRH3 and CDRL3 lengths are 15 (CDRH3) and 9–10 (CDRL3) amino acids.
  3. *IC50 value calculated against authentic SARS-CoV-2 virus.
  4. **IC50 values varied depending on neutralization assay used.
  5. †Unknown IC90 values indicated as NA (not available).
  6. §Potential for intra-spike crosslinking by an IgG binding to a single spike trimer was evaluated as described in the Methods.
  7. ?Sequence information not available.
  8. ???Inference that cannot be made from a structure of a Fab bound to a RBD.
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