Extended Data Fig. 5: Macaque CD4⁺ and CD8⁺ T cell response.

Macaques (n = 6 per group) were injected on day 0 and day 21 with 30 μg or 100 μg BNT162b2, as in Figs. 3, 4. PBMCs collected on days 0, 14, 28 and 42 after BNT162b2 injection were ex vivo restimulated with full-length S peptide mix. a, Scatter plot showing the correlation of IL-4- and IFNγ-secreting cells by ELISpot of day-42 PBMCs. b, IFNγ, IL-2 or TNF release from CD4⁺ T cells by flow cytometry (LLOD = 0.04). c, IL-4 release from CD4⁺ T cells by flow cytometry (LLOD = 0.05). d, IFNγ release from CD8⁺ T cells by flow cytometry (LLOD = 0.03). Heights of bars indicate the arithmetic means for each group. Whiskers indicate s.e.m. (b–d). Each symbol represents one macaque. Horizontal dashed lines mark LLODs. Values below the LLOD were set to 1/2 the LLOD. Arrows below the x axis indicate the days of doses 1 and 2.