Extended Data Fig. 10: Working model for centromere dismantlement in meiosis. | Nature

Extended Data Fig. 10: Working model for centromere dismantlement in meiosis.

From: Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8

Extended Data Fig. 10

Meiotic Spo11 and Rec8 binding to chromatin (1) destabilizes CenpA nucleosomes; (2) their dismantlement propagates outwards to surrounding pericentric heterochromatin (HC) (3). (4) Telomeres, which are in close proximity to centromeres during bouquet formation in meiotic prophase, provide a microdomain that favours centromeric reassembly.

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