Extended Data Fig. 8: Comparison of the Gi binding pocket among class-A, -B, -C and -F GPCRs.
From: Structural basis of GABAB receptor–Gi protein coupling
a–c, Parallel comparisons of the Gi binding pocket between the GABAB and class-A CB1 (a), class-B GCGR (b) and class-F SMO (c) receptors. Four structures were aligned by the class-A TMD as a reference, as in Fig. 2. A comparison of the indicated two receptors is shown. Colours for α5 are: GABAB-bound, yellow; CB1-bound (PDB 6N4B), orange–red; GCGR-bound (PDB 6LML), sky blue; and SMO-bound (PDB 6OT0), magenta.
