Extended Data Fig. 9: Proposed model of GABAB activation.
From: Structural basis of GABAB receptor–Gi protein coupling
a–d, Schematic of the essential steps for GABAB activation. e, Comparison of the relative bending of GB2 subunit in the agonist- and PAM–Gi-bound (ago/PAM-Gi) (green), the agonist-bound (ago) (PDB 6UO9) (blue), and antagonist-bound (antago) (PDB 7C7S) (yellow) when aligned on the GB2 VFT. f, The transmembrane domain rearrangement of GABAB during activation. The antagonist-bound (antago) (PDB 7C7S) (yellow), agonist-bound (ago) (PDB 6UO9) (blue), and the agonist- and PAM–Gi-bound (ago/PAM–Gi) (green) structures of the TMD of GABAB were aligned by the TMB of GB1. g, PAM binding in agonist- and PAM–Gi-bound GABAB (ago/PAM–Gi).
