Extended Data Fig. 7: Long-term effects of adenine base editing of PCSK9 on lipoprotein(a) in cynomolgus monkeys.
From: In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
Changes in the blood lipoprotein(a) level in the six monkeys from Fig. 3a, comparing levels at various time points up to 238 days after treatment versus the baseline level before treatment. Mean ± s.d. for the LNP-treated group (n = 4 monkeys) and mean for the control group (n = 2 monkeys) at each time point). The dotted lines indicate 100% and 65% of baseline levels.
