Extended Data Fig. 9: Additional studies with cynomolgus monkeys receiving a dose of 3.0 mg kg−1 of LNPs. | Nature

Extended Data Fig. 9: Additional studies with cynomolgus monkeys receiving a dose of 3.0 mg kg−1 of LNPs.

From: In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates

Extended Data Fig. 9: Additional studies with cynomolgus monkeys receiving a dose of 3.0 mg kg−1 of LNPs.The alternative text for this image may have been generated using AI.

Levels of liver editing of the PCSK9 exon 1 splice-donor adenine base (at day 15), blood AST and blood ALT. n = 3 monkeys treated with PBS, n = 4 monkeys treated with a dose of 3.0 mg kg−1 LNPs containing ABE8.8 mRNA and non-PCSK9-targeting gRNA and n = 4 monkeys treated with a dose of 3.0 mg kg−1 ABE8.8 and PCSK9-1 LNPs. Bar indicates mean value at each time point.

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