Extended Data Fig. 2: High-dimensional identification of the incident post-acute sequelae in people who were hospitalized for COVID-19.

a–f, incident diagnoses (a, d), incident medication use (b, e) and incident laboratory abnormalities (c, f). Individuals who were hospitalized with seasonal influenza served as the referent category. Post-acute sequelae were ascertained from 30 days after infection until the end of follow-up. a–c, Beginning from the outside ring, the first ring represents hazard ratios for the post-acute sequelae of COVID-19. A higher bar indicates a larger hazard ratio. Hazard ratios with a point estimate larger than one and that are statistically significant are coloured in yellow. The second ring represents excess burden per 1,000 patients with COVID-19 at 6 months. Colour of the cell indicates value of the excess burden; deeper shades of red indicate higher excess burden and deeper shades of blue indicate greater reduced burden. The third ring represents the baseline incident rate in the control group; deeper shades of red indicate higher incident rate. The fourth ring represents negative log of the P value; a higher bar indicates a smaller P value and yellow indicates statistically significant. d–f, Sequelae were selected based on having a hazard ratio larger than one and P value less than 6.57 × 10⁻⁵. Excess burdens per 1,000 patients with COVID-19 at 6 months are presented. Within each domain, outcomes are ranked based on excess burden from high to low. Diagnoses are coloured based on diagnosis group, medications are coloured based on medication class, and laboratory abnormalities are coloured based on higher or lower than normal range.