Extended Data Fig. 5: Sequence alignment of the TMDs of human mGlus.
From: Structures of human mGlu2 and mGlu7 homo- and heterodimers
Colours represent the similarity of residues: red background, identical; red text, strongly similar. The red arrows indicate the positions with mutations in the inactive mGlu2 and mGlu7 structures (2, mGlu2; 7, mGlu7). The mGlu2 residues that are involved in TMD dimerization in the inactive mGlu2 structure are indicated by green arrows. The conserved residues with the modified Ballesteros–Weinstein numbers for class C GPCRs 1.50, 2.50, 3.50, 4.50, 5.50, 6.50 and 7.50 are indicated by black arrows. The alignment was generated using UniProt (http://www.uniprot.org/align/) and the graphic was prepared on the ESPript 3.0 server (http://espript.ibcp.fr/ESPript/cgi-bin/ESPript.cgi).
