Extended Data Fig. 10: Hi-C mapping reveals the chromatin loops specific to cells with the LLPS-competent NUP98–HOXA9, compared with the LLPS-competent mutant, at leukaemia-relevant gene loci.
From: Phase separation drives aberrant chromatin looping and cancer development
Views for Hi-C mapping, RNA-seq and ChIP–seq for CTCF, N-IDR/A9 and H3K27ac at the HOXB (a), EYA4 (b), and SKAP2-HOXA loci (c) in 293FT stable cells expressing either N-IDRWT/A9 (WT) or N-IDRFS/A9 (FS). Hi-C mapping views (top) show results from the N-IDRWT/A9 or N-IDRFS/A9 expressing cells (bottom and top diagonal, respectively). Corresponding ChIP–seq and gene tracks are shown below each Hi-C plot. N-IDRWT/A9 loops are indicated by red arrows.
