Extended Data Fig. 11: Model illustrating requirement of LLPS-competent IDR within NUP98–HOXA9 for leukaemogenesis and activation of the oncogenic gene-expression program. | Nature

Extended Data Fig. 11: Model illustrating requirement of LLPS-competent IDR within NUP98–HOXA9 for leukaemogenesis and activation of the oncogenic gene-expression program.

From: Phase separation drives aberrant chromatin looping and cancer development

Extended Data Fig. 11

The LLPS-competent IDR contained with NUP98–HOXA9 is crucial for promoting long-distance chromatin looping between proto-oncogene promoter and enhancers, which thus induces an oncogenic gene-expression program and malignant development.

Back to article page