Extended Data Table 1 Dok7CM/CM mice on a mixed genetic background survive for approximately two weeks postnatally

From: Mechanism of disease and therapeutic rescue of Dok7 congenital myasthenia

  1. We used a mixed genetic background of mice to analyse the survival of Dok7CM/CM mice. Dok7CM/+ mice on a C57BL/6 background were crossed to wild-type CBA, 129sv1, FVB, or BALB/c mice. Heterozygous F1 progeny were then intercrossed to produce Dok7CM/CM mice on a mixed background. We determined the genotype of the progeny at P5–P10 or post-mortem. a, χ2 analysis of F2 mice shows that the occurrence of genotypes is unlikely to occur by chance, indicating that homozygous Dok7CM/CM mice in each mixed genetic background survive postnatally. b, The table shows the average and maximum survival time (days) of homozygous Dok7CM/CM mice on a mixed genetic background. Despite surviving for up to three weeks after birth, DOK7 expression, MUSK phosphorylation and the organization of nerve terminals and AChRs were similar in E18.5 inbred C57BL/6 and mixed breed C57BL/6-CBA mice carrying the same Dok7 mutation.
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