Extended Data Fig. 7: Characterization of a catalogue of super-enhancers in fibroblasts, myeloid cells and endothelial cells.

a, Distribution of accessibility in fibroblasts, myeloid cells and endothelial cells in the TAC state identifies a class of distal regions (super-enhancers (SE)) for which the accessibility falls over the inflection point of the curve. b, c, Volcano plots showing correlation coefficients and corresponding P values (refer to the analysis depicted in Fig. 2e) of 239 super-enhancers in myeloid (b) and 267 super-enhancers in endothelial (c) cells. d, Distribution of H3K27ac in unstimulated and TGFβ-treated fibroblasts identifies a class of distal regions (super-enhancers) for which the accessibility falls over the inflection point of the curve. e, Fraction of H3K27ac in unstimulated and TGFβ-treated fibroblasts for the enhancers identified in vivo having a negative (left, n = 264) or positive (right, n = 206) correlation with heart function (based on analysis depicted in Fig. 2e). Box plots show the 25th, 50th and 75th percentiles, with whiskers extending to the furthest value no further than 1.5× the interquartile range.